Cascon A [30] reported that the lack of MAX in PC12 cells (derived from rat adrenal pheochromocytoma) make it easier to experience tumorigenesis, Albanus RD [31] reported that the expression level of MAX is positively correlated to the survival rate of breast cancer and lung cancer patients, Comino-Méndez I [32] reported that the loss of function of MAX would increase the invasiveness of pheochromocytoma, Yang L [33] reported that the loss of expression of MAX may activates the pathogenesis of pancreatic cancer. This evidence concerns the gene MAX and hereditary pheochromocytoma-paraganglioma.