In addition, in combination with the information from the Disease Ontology database, we found that 12 known primary hepatic cancer (PHC) related genes, including MYC, CDC16, DDR1, EBAG9, IGF2, KDR, MAD2L2, MEF2C, NDRG2, SIX1, TNFRSF10B and TSGA10, were HyperM in the arsenic-exposure group. The gene discussed is MAD2L2; the disease is liver cancer.