ECM can provide a protective environment against drug effects, thus favoring the emergence of chemoresistant cancer cells [39]; for instance, fibronectin was found directly involved in the mechanisms of cell adhesion-mediated drug resistance of MM cells [40], whereas collagen degradation in the BM ECM by matrix metalloproteinases may contribute to MM progression [41]. The gene discussed is FN1; the disease is Miyoshi myopathy.