In particular, as regards TP53 mutations, it should be noted, as aforementioned, that all the four TP53-mutated cases also carried del(17p), and the frequent co-occurrence of these two genetic alterations is compatible with the demonstrated association of TP53 inactivation with advanced forms of malignancy (also substantiated by its nearly ubiquity in MM cell lines) [29]. This evidence concerns the gene TP53 and Miyoshi myopathy.