In order to identify the possible role of MUC16 in modulating distinct metabolic pathways in tumor cells, we evaluated the polar metabolite contents of control and MUC16 knockdown Colo357 pancreatic cancer cells and that of the MUC16-high and MUC16-low rapid autopsy pancreatic tumor specimens, as determined by IHC. Here, MUC16 is linked to neoplasm.