The predictive and prognostic role of beta-tubulin isotypes expression in urothelial bladder carcinoma has been recently evaluated, suggesting an interesting association between high beta-1-tubulin, beta-2-tubulin, beta-tubulin-3 expressions and unfavourable clinico-pathologic factors (like tumour grade and stage), and shorter recurrence-free survival [23]. The gene discussed is TUBB4B; the disease is bladder transitional cell carcinoma.