Besides, although the nuclear components, including Sp100, promyelocytic leukemia proteins and two components of the nuclear pore complex protein (gp210 and nucleoporin 62), react with ANA, as has been previously demonstrated, anti-sp100 antibody is not a better prognostic marker for Chinese patients with PBC compared to anti-gp210 antibody, which was only detected in 34.3% of Chinese patients with PBC (6). Here, SP100 is linked to primary biliary cholangitis.