GLS2 and colonic neoplasm: It has been reported that knockdown GLS2 (GLS) by siRNA increased ROS production and oxidative DNA damage in colon cancer cells and elevated GLS2 expression was necessary for cells to maintain intracellular levels of glutamate, α-ketoglutarate, GSH, and ROS (Hu et al. 2010, Suzuki et al. 2010).