Given the complementary evidence that P-selectin-deficient mice do not develop cerebral malaria [6] and that ECM pathology is limited in susceptible mice infected with ΔPbMSP7 parasites [36], it is tempting to speculate that the interaction between P-selectin and MSP7 exacerbates the pathological processes involved in the development of cerebral malaria. Here, SELP is linked to cerebral malaria.