Various studies have shown that ciliopathies, such as Lowe, Joubert, and Bardet-Beidl syndromes, have defects in RhoA or Rac1 localization or activity (Hernandez-Hernandez et al., 2013; Madhivanan et al., 2012; Valente et al., 2010). Here, RAC1 is linked to ciliopathy.