C2CD3 and orofaciodigital syndrome: C2CD3-dependent OFD represents the 14th OFD subtype (OMIM 615948) (Thauvin-Robinet et al., 2014), strongly suggesting that the ta2 mutant, previously shown to be caused by a mutation in C2CD3, could be classified as a novel generalized model for OFD, which is particularly relevant to OFD14.