For example, miR-29, a miRNA regulated by GATA3, inhibits metastasis by targeting a network of pro-metastatic regulators involved in angiogenesis, collagen remodeling and proteolysis, suggesting that a miRNA can function by altering the tumor microenvironment (Chou et al., 2013; Melo and Kalluri, 2013). The gene discussed is GATA3; the disease is neoplasm.