Remarkably, the amino acids that are crucial for LPL activation in the last helix of human APOC2 are conserved in zebrafish, and the human APOC2 mimetic peptide C-II-a (Amar et al., 2015), rescued severe hypertriglyceridemia in apoc2 mutant zebrafish (Fig. 6). The gene discussed is LPL; the disease is hypertriglyceridemia.