APOC2 and hyperlipidemia: Current genetic animal models to study hyperlipidemia include mice with a conditional deficiency in LPL, deficiency of GPIHBP1, or with overexpression of human APOC2 and APOC3 (Ebara et al., 1997; Goulbourne et al., 2014; Shachter et al., 1994; Weinstein et al., 2010).