APOC2 and hypertriglyceridemia: In agreement with epidemiologic studies suggesting that hypertriglyceridemia is a risk factor for CVD (Do et al., 2015; Jørgensen et al., 2014; The TG and HDL Working Group of the Exome Sequencing Project, National Heart, Lung, and Blood Institute et al., 2014), our results demonstrate that the hypertriglyceridemia induced by the apoc2 mutation in zebrafish results in vascular lipid accumulation and macrophage lipid uptake (Fig. 7C-E), which are important initial events in the development of human atherosclerosis.