Similarly, a NPRL2-mediated tumor suppression effect has also been demonstrated in NPRL2-deficient KRC/Y renal cell carcinoma cells, U2020 small-cell lung carcinoma cells and A549 non-small-cell lung cancer cells, following the induction of the expression of NPRL2 at a physiological level (5). The gene discussed is NPRL2; the disease is hereditary clear cell renal cell carcinoma.