Meanwhile, carbachol induces contraction of the smooth muscle cells by releasing sarcoplasmic calcium, followed by rapid entry of calcium to the cells [23, 24], thereby stimulating 1,4,5-inositol trisphosphate receptors (IP3Rs) and ryanodine receptors (RyRs) [25], both of which are involved in asthma pathophysiology [26]. Here, ITPR1 is linked to asthma.