To the best of our knowledge, this report is the first of show that hASCs modified by HIF-1α offered better protective effects on renal function and tubular structure by decreasing renal tubular apoptosis, suppressing inflammation and stimulating HO-1 gene expression, and our study also demonstrated that a paracrine effect played an important role in treating cisplatin-induced AKI in nude rats by the implantation. This evidence concerns the gene HIF1A and acute kidney injury.