Multivariate analysis of disease progression factors revealed that maximum tumor size (>5 cm) (HR: 1.72; 95% CI: 1.18–2.51; P = 0.005), EHS (HR: 1.75; 95% CI: 1.15–2.65; P = 0.008), albumin (≤3.4 g/dL) (HR: 1.87; 95% CI: 1.27–2.77; P = 0.002), and alanine aminotransferase (ALT) (>45 IU/L) (HR: 1.51; 95% CI: 1.05–2.17; P = 0.028) were significantly associated with disease progression in the HAIC group (Table4). The gene discussed is GPT; the disease is neoplasm.