Tunicamycin or MG132 treatment ofMiaPaCa-2 and T3M4 pancreatic cancer cells stably transfected with CMV9-F114HAresulted significant abrogation of higher molecular weight forms and increasedaccumulation of MUC16-Cter, respectively (Fig. 2a)suggesting MUC16-Cter undergoes N-glycosylation and ubiquitylation. The gene discussed is MUC16; the disease is familial pancreatic carcinoma.