MUC5AC and cancer: Recent studies havefurther underscored its importance; owing to its de novo and/or increasedexpression in cancer5, 6, 7 as well as being one of the topthree frequently mutated genes across various cancer types42.Given the importance of oncogenic signaling mediated by mucin cytoplasmic tailfollowing cleavage2, we investigated the speculations aboutMUC16 cleavage12, 14.