TRPM4 and hypertensive disorder: Considering that hypertension and increased plasma catecholamine levels, which can influence the tendency to develop hypertrophy, were recently reported in global TRPM4-deficient mice [25], we have generated a cardiac-specific TRPM4 knockout mouse line (Trpm4cKO), through crossbreeding of Trpm4flox mice with MLC2a-Cre mice [40] (Fig. 1a).