IL10 and neoplasm: On the other hand, M2 and M2-like macrophages polarize in response to IL-4 and IL-13, IL-10 or glucocorticoid hormones and are generally described to present low IL-12 and IL-6 and high IL-10 expression, as well as an increased ability to scavenge, repair and remodel tissue, promoting angiogenesis and tumour progression [22, 23].