Co-expression of all three markers (Rb1, P16 and ER) was seen in 10, 10, 6 and 0 % of high grade serous carcinoma (HGSC), low grade serous carcinoma (LGSC), endometrioid carcinoma (EC) and mucinous carcinomas, respectively. This evidence concerns the gene ESR1 and mucinous adenocarcinoma.