These 21 genes significantly over-represent genes highly expressed in prostate cancer cells after knockdown of EZH2 [16] (p = 0.009, OR = 5.8) and genes down-regulated in fibroblasts expressing mutant forms of ERCC3 after UV irradiation [24] (P = 0.0046, OR = 7.1). This evidence concerns the gene EZH2 and Familial prostate cancer.