CCK and Anorexia: Using the NPY2 antagonist BIIE0246 and CCK1A receptor antagonist devezapide, it was suggested that PPY may be a critical mediator of DON-induced anorexia, while CCK is not [38]; however, opposing results were found when Wu et al. tested CCK1 and CCK2 receptor antagonists SR 27897 and L-365,260.