In conclusion, we showed that CCCs are statistically more likely to exhibit whole-arm CNAs, and that focal LOH in SC correlates BRCA1/2 genes with other major tumor suppressor genes, including TP53, RB1, and NF1. Our observations also suggest that some differentially expressed genes in CCC-2 (such as UGT1A, STAT3, HIF2A, E2F-RB and extracellular matrix genes) may serve as possibly favorable prognostic indicators. The gene discussed is EPAS1; the disease is neoplasm.