TRPV4 and motor neuron disorder: In addition to its involvement in cerebral ischemic injury, the potential role of TRPV4-induced neurotoxicity has been reported in AD and motor neuron disease.6, 8, 26 An increase in TRPV4 expression has been found in the brains of aged rats.3 Therefore, targeting of TRPV4 provides a promising neuroprotective treatment.