Statins mediate their action via suppression of Th17 differentiation with the concurrent induction of Treg differentiation.16 Emerging evidence suggests that statins inhibit the release of airway neutrophilic mediators (CXCL8, IL-6, and granulocyte-macrophage colony-stimulating factor) from bronchial epithelial cells and suppress their upregulation by IL-17.17 Interestingly, all of these additional actions may counteract the neutrophilic inflammation-promoting effects of IL-17 in COPD. This evidence concerns the gene CXCL8 and chronic obstructive pulmonary disease.