IL17A and multiple sclerosis: Statins, however, have additional pleiotropic pharmacologic effects, including antiinflammatory, antioxidant, and immunomodulatory activities in vitro and in vivo.12‐15 The immunomodulatory effects of statins on Th17 cell- and IL-17-mediated inflammatory responses have been well established in autoimmune diseases, including multiple sclerosis in humans and experimental autoimmune encephalomyelitis in mice.