Patients with COPD treated with simvastatin had higher concentrations of IL-10 in sputum supernatants compared with the baseline levels, whereas there was no significant increase of IL-10 in patients with COPD who received placebo (median [IQR], 28.8 pg/mL [17.5-41.7 pg/mL] vs 7.2 pg/mL [5.9-9.0 pg/mL], P < .001; 8.3 pg/mL [6.5-10.0 pg/mL] vs 8.1 pg/mL [6.6-9.5 pg/mL], P = .78, respectively). This evidence concerns the gene IL10 and chronic obstructive pulmonary disease.