Among these four groups, significant differences were observed for gender {KRAS (+)/dMMR cases more likely to be male, P < 0.0001}, age {KRAS (+)/dMMR more likely to have a younger age at diagnosis of disease, P = 0.0001}, grade {KRAS (-)/dMMR more likely to have lower grade disease, P = 0.002}, tumor location {KRAS (+) and KRAS (-)/dMMR cases more likely to be located in the proximal colon, P < 0.0001}and lymph node metastasis {KRAS (+)/pMMR cases more likely to have higher pN stage, P = 0.004}. This evidence concerns the gene KRAS and neoplasm.