ACHE and Alzheimer disease: The present study investigated the ability of AP-12: 1) to improve cognitive functions in wild type C57BL/6J mice and Alzheimer’s disease model Tg APPSweDI mice; 2) to penetrate the BBB in C57BL/6J mice, 3) to affect amyloid-beta deposition in transgenic mice; 4) to influence the expression of hippocampal and cortical proteins: Homer-1, GAD67 (glutamate decarboxylase 67), and AChE (acetylcholinesterase).