However, knockdown of hMLH1 in HeLa (S4B Fig) and another colon cancer cell line, HT29 (S4C Fig), did not sensitize these cells to 1d-induced apoptosis, which suggests that the mismatch repair defect in HCT116 cells may not be responsible for its sensitivity to 1d. Here, MLH1 is linked to malignant colon neoplasm.