CDK8 and metabolic dysfunction-associated steatotic liver disease: Since CDK8 negatively regulates nSREBP-1c protein degradation [10], our results of CDK8 down-regulation in NAFLD suggest that the protein stability of nSREBP-1c is increased in NAFLD, although other mechanisms of SREBP-1c regulation, such as transcription and maturation, may also contribute to the accumulation of nSREBP-1c.