In the CAN/DF dataset, the high-risk group, based, respectively, on the HMGB1 / RAGE signaling pathway, beta-adrenergic receptor regulation of ERK pathway and clathrin-coated vesicle cycle pathway, had a median survival of 71, 38 and 37 months, while the low-risk group did not reach median survival. The gene discussed is HMGB1; the disease is Crouzon syndrome-acanthosis nigricans syndrome.