In addition, patients with type 2 diabetes and NAFLD who carried the GG genotype of rs266729 had significantly lower serum HMW adiponectin levels than patients with NAFLD who carried the GC or CC genotype (3.75±0.37 vs.3.99±0.66 vs. 4.79±0.58 μg/ml, p< 0.001). This evidence concerns the gene ADIPOQ and metabolic dysfunction-associated steatotic liver disease.