In patients with type 2 diabetes but without NAFLD, there was no significant difference in plasma HMW adiponectin levels between patients with different genotypes (GG: 4.94±0.44 vs. GC: 5.00±0.54 vs. CC:5.02±0.30μg/ml, p = 0.39). This evidence concerns the gene ADIPOQ and type 2 diabetes mellitus.