This was also confirmed by a recent meta-analysis revealed that adiponectin gene rs17300539 and rs1501299 polymorphisms are associated with an increased risk of obesity in Caucasians and that the rs266729 polymorphism is associated with risk of obesity in Asians and there is no associations between rs2241766 and the obesity risk [31]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.