A few human studies, including ours, have examined the relationship between phthalates exposure, particularly DEHP, and serum thyroid profiles in adults, adolescents, or children (S4 Table).[10,11,15,39] Meeker and his coworkers firstly studied 408 men and collected their blood and one-spot urine samples when they visited one Fertility Center in Massachusetts, USA, for infertility evaluation.[10] They measured six phthalate metabolites, including MEP, MBP, MBzP, MEHP, MEHHP, and MEOHP in urine and TSH, FT4, and T3 in serum. This evidence concerns the gene MBP and Infertility.