Macronodular hyperplasia, previously known as massive macronodular adrenocortical disease (MMAD) or ACTH-independent macronodular adrenocortical hyperplasia (AIMAH), has been recently renamed as primary macronodular hyperplasia (PMAH) after the discovery of intra-adrenal ACTH production (Lacroix, 2013; Louiset et al., 2013). The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.