Subsequently, numerous central and peripheral actions of ghrelin were described, including stimulation of gut motility and gastric acid secretion [5,6], modulation of sleep [7–9], taste sensation and reward seeking behavior [10–16], regulation of glucose metabolism [17–20], suppression of brown fat thermogenesis [21–25], modulation of stress and anxiety [26–28], protection against muscle atrophy [29,30], and improvement of cardiovascular functions such as vasodilatation and cardiac contractility [31–34] (Figure 1). Here, GHRL is linked to Anxiety.