Work by the laboratories of Joseph Goldstein and Michael Brown in young fat-depleted GOAT ko mice showed that acyl-ghrelin is of crucial importance for preventing life-threatening events of hypoglycemia under conditions of acute caloric restriction, an effect attributable to ghrelin's ability to promote the release of GH from the anterior pituitary [20,168,169]. This evidence concerns the gene GH1 and Hypoglycemia.