HSPA8 and systemic lupus erythematosus: It is also supported by in vivo data demonstrating that upon treatment of MRL/lpr mice with the P140 peptide, the levels of two key CMA components, namely LAMP-2A and HSPA8, which are over-expressed in lupus mice are significantly decreased in B cells of treated mice (Figures 3D–F) (75, 76).