It is therefore possible that a modification in the stability of LAMP-2A occurs in the lupus model, and since HSP90 is involved in the stabilization of LAMP-2A (159), the weaker stability of LAMP-2A could in fact result from the effect of P140 with the HSPA8 heterocomplex containing HSP90. The gene discussed is HSPA8; the disease is systemic lupus erythematosus.