Following the discovery that several ATGs could be associated to autoimmune syndromes, e.g., ATG5, PR domain zinc finger protein 1 (PRDM1; also known as BLIMP-1), DNA-damage regulated autophagy modulator 1 (DRAM1) in SLE patients (52–56), or ATG16L1 and immunity-related GTPase M (IRGM) in Crohn’s disease and ulcerative colitis (57–61), further studies, at the cellular and molecular levels, were undertaken. Here, IRGM is linked to Crohn disease.