Neurotoxic stimuli, such as ischemia (4, 9), glutamate (5), β-amyloid (7, 24), or 1-methyl-4-phenylpyridinium (MPP+) (25, 26), induce p50/RelA dimers activation and the transcription of a panel of pro-apoptotic genes (4). Here, RELA is linked to ischemia.