Since gating currents in ClC-5 reflect the existence of incomplete silent transport cycles, i.e., conformational changes that are not associated with electrogenic chloride/proton exchange (Grieschat and Alekov, 2012), the encountered differences suggest that the probability for completing the transport cycle with ions being transported through the membrane is altered by both here investigated Dent's disease mutations. Here, CLCN5 is linked to Dent disease.