Moreover, additional studies in which PHD2 was either inactivated globally (Minamishima et al., 2008), or in a cardiomyocyte-restricted manner (Holscher et al., 2011), have also demonstrated submaximal HIF activation accompanied with a mild mitochondrial swelling (Minamishima et al., 2008) together with increased expression of Glut1, Pgk, Pfkl and Pdk1 genes and protection against myocardial infarction (Holscher et al., 2011). The gene discussed is EGLN1; the disease is myocardial infarction.