Recent exciting evidence has connected AβO-induced neuronal stress to cognitive impairments in AD, in a mechanism that includes cytokine-induced activation of stress kinases and ultimately leads to neuronal and synapse dysfunction in AD experimental models (De Felice et al., 2007; Yoon et al., 2012; De Felice, 2013; Lourenco et al., 2013; Ma et al., 2013; Baleriola et al., 2014; De Felice and Ferreira, 2014; Ferreira et al., 2014). This evidence concerns the gene ABO and Alzheimer disease.