EIF2AK2 and Alzheimer disease: Indeed, abnormal phosphorylation of p38 MAPK (Hensley et al., 1999), JNK (Ma et al., 2009; Bomfim et al., 2012; Yoon et al., 2012), PERK (Hoozemans et al., 2005, 2009), PKR (Chang et al., 2002a; Paquet et al., 2011) and IKK (Talbot et al., 2012) have been reported in AD brains and might be core mediators of neuronal dysfunction.