EIF2AK4 and Alzheimer disease: Two other eIF2α kinases, namely the stress kinase PKR and the nutrient sensor GCN2, are enriched in the brain and have been reported to increase neuronal eIF2α-P (Costa-Mattioli et al., 2005; Lourenco et al., 2013; Roffé et al., 2013; Hetz and Mollereau, 2014), and thus emerge as candidates to explain increased eIF2α-P in AD.