Oligomers promote neuronal stress by instigating abnormal elevations in levels of tumor necrosis factor α (TNF-α) and reactive oxygen species (ROS), as well as activation in JNK/PKR signaling and increased eIF2α phosphorylation (eIF2α-P) levels in AD models (De Felice et al., 2007, 2014; Ma et al., 2009, 2013; Bomfim et al., 2012; Lourenco et al., 2013). Here, EIF2A is linked to Alzheimer disease.