However, a significant reduction was observed in the oldest mice (18 months), indicating an inverse relationship with tauopathy detected levels, which is supported by an inverse correlation between autophagy-related markers downregulation and the increase in tau aggregates (Meske et al., 2008; Majumder et al., 2011; Schaeffer et al., 2012; Ozcelik et al., 2013). The gene discussed is MAPT; the disease is tauopathy.