Also, our data showed increased mTOR activity in the early and late stages of the 3xTg-AD model, suggesting that mTOR activity in the late phase may be closely related to high levels of hyperphosphorylated tau (Moreau et al., 2010; Caccamo et al., 2013) and that decreased levels of Bcl-2 may be related to cell death in the advanced stages of the disease (Rodriguez et al., 2011). Here, MAPT is linked to Alzheimer disease.