HSPA8 and hypoxia: Previous studies have demonstrated an increase in the expression of Hsc70, LAMP-2, and Hsp90 mRNAs, the proteins function together to remove protein aggregates and block neuronal apoptosis (Kobayashi et al., 2000) at 48 h after CI or cerebral hypoxia (Kitagawa et al., 1990; Kirino et al., 1991; Tanaka et al., 2002).