These observations were supported by the increased AT-8 protein levels at 12 months and PHF-1- protein levels at 18 months in the 3xTgAD mice compared with the internal controls for each age group (Figure 1D), confirming the direct relationship between tauopathy and disease progress, as previously described (Oddo et al., 2003). The gene discussed is PHF1; the disease is tauopathy.