HSPA8 and Alzheimer disease: Our data showed that the chaperone-assisted ubiquitin ligase (CHIP) was not modified (Figure 7A), Hsc70 was down-regulated at 12 and 18 months in the 3xTg-AD mice (Figure 7B) and that Hsp90 was increased at 6 months, but there were not changes in these protein levels at 12 and 18 months (Figure 7C).