PHF1 and Alzheimer disease: To confirm the interdependency between the levels of hyperphosphorylated tau and macroautophagy, we evaluated the immunofluorescence intensity of PHF-1 and LC3B in the primary somatosensory cortex in the short, intermediate, and long-term progression of chronic injury (3xTg-AD at 6, 12, and 18 months, respectively) and acute injury (CI – 2VO at 1, 15, and 30 days post-ischemia).