RBFOX3 and ischemia: In the global CI rat model, the penumbral area in the somatosensory cortex, which is closest to the focus in the region of the middle cerebral artery, demonstrated a significant reduction in the NeuN immunoreactivity (Figure 1B) at day 1 (2,322 ± 109 nuclei) and day 15 (2,531 ± 185 nuclei) post-ischemia compared with the control rats (2,780 ± 158 and 3,395 ± 206, respectively).