Several studies have demonstrated senile plaques (βA) and amyloid precursor protein (APP) in close proximity to the ischemic focus (Ikeda et al., 2000; Shi et al., 2000), suggesting a degree of convergence in the neuropathogenesis of CI and AD (Jablonski et al., 2011; Song et al., 2013). Here, APP is linked to Senile plaques.