We evaluated the temporal course of phosphorylated tau using AT-8 and PHF-1 antibodies in short-term, intermediate, and long-term disease progression in the somatosensory cortex of chronic injuries, such as in AD (at 6, 12, and 18 months) and in acute injury, such as CI (2VO at 1, 15, and 30 days post-ischemia). The gene discussed is PHF1; the disease is Alzheimer disease.