MAPT and stroke disorder: However, autophagic activity may play an important role in neuroprotection after an ischemic event, resulting in a beneficial effect on the cerebral cortex and hippocampus to prevent protein aggregation after stroke (Rami, 2009; Guo et al., 2010; Liu et al., 2010, 2013a,b; Zhou et al., 2011), and autophagic degradation has been proposed as an important regulator of hyperphosphorylated tau levels after an acute injury (e.g., in CI; Liu et al., 2010; Marino et al., 2011; Schaeffer and Goedert, 2012), which is consistent with our findings.