BACE1 and Alzheimer disease: miR-124 level is down-regulated (human-originated, n = 5; Lukiw, 2007), while the expression of β-site APP cleaving enzyme 1 (BACE1) is up-regulated, in AD patients’ brain (Bigl et al., 2000; Sun et al., 2002; Yang et al., 2003; Lukiw, 2007; Smith et al., 2011), indicating a possible inverse relationship between them.