Xia et al. (2012) demonstrated that the tumor suppressor activity of miR-124 could by partly due to its inhibitory effects on glioma stem – like traits and invasiveness through down-regulation of SNAI2 in human. Others reported that miR-124 inhibits glioma cells migration and invasion by down-regulation of ROCK1 (An et al., 2013), and induced glioma differentiation by suppressing Twist and SNAI2 (Xie et al., 2012). Here, TWIST1 is linked to central nervous system cancer.