EIF2A and amyotrophic lateral sclerosis: For phospho-eIF2α/total eIF2α there was a genotype × age interaction effects with the increase in ALS-Tg only increasing between 70d and 120–140d (70d vs. 90d; p = 0.227; 70d vs. 120–140d p = 0.018; 90d vs. 120–140 p = 0.062).