CRYAB and amyotrophic lateral sclerosis: Supporting our data, a recent study using proteomics and bioinformatics tools reported activation of stress responses in gastrocnemius muscle of ALS-Tg mice at 98d including Alpha-crystallin B chain (Cryab), Heat shock protein HSP 90-beta (Hsp90ab1) and protein disulfide-isomerase A3 (Pdia3) that suggest abnormalities in the ER protein folding machinery and activation of the UPR (Capitanio et al., 2012).