In WG of ALS-Tg mice, CHOP was upregulated 1.8-fold at 70d (p = 0.041), remained elevated at 90d (p = 0.025) and further increased to 12-fold at 120–140d (p = 0.019; Figures 6A,B). The gene discussed is DDIT3; the disease is amyotrophic lateral sclerosis.