EIF2A and amyotrophic lateral sclerosis: In WG muscle, the ratio of phospho-eIF2α/total eIF2α was increased 2.3-fold in ALS-Tg vs. WT at 70d (p = 0.005), remained elevated at 90d (p = 0.048) and increased further to 12-fold at 120–140d (p = 0.011; Figures 2A,B).