TNF and Alzheimer disease: The promoter region SNPs of TNF gene, rs1800629 and rs1799724, have been studied for a possible involvement with a functional alteration in the production of this proinflammatory cytokine, in particular the presence of the rs1799724 in Caucasians with a diagnosis of probable AD, correlated with altered levels of Aβ42 in CSF (Laws et al., 2005).