TNF and Alzheimer disease: Numerous studies have examined the presence of SNPs in genes of proinflammatoy cytokines such as Interleukin-1α (IL-1α; Combarros et al., 2002), Interleukin 6 (IL-6; Chen et al., 2012), Tumor Necrosis Factor α (TNF-α; Laws et al., 2005; Ardebili et al., 2011) and in the anti-inflammatory Interleukin 10 (IL-10; Bagnoli et al., 2007), whose production have found altered in CSF and peripheral blood in AD patients (Blum-Degen et al., 1995; Swardfager et al., 2010).