One class comprises proteins that in most, but not all, studied contexts promote cell proliferation and migration, often by disrupting or weakening cell adhesions and multicellular integration (e.g., TGF-beta, growth factors, cytokines, and proto-oncogenes), whereas the second class comprises proteins that exert opposite effects, i.e., inhibit cell proliferation and migration, often by promoting cell adhesion and integration (e.g., cadherins, integrins, cell junction scaffolds, and tumor suppressors). The gene discussed is CDH17; the disease is neoplasm.