In CLL as well as in other hematologic malignancies, the over-expression of the anti-apoptotic Mcl-1 and Bcl-2 proteins is one of the major causes of apoptosis resistance [19, 20], poor prognosis [21, 22] and chemoresistance [23-25]. The gene discussed is BCL2; the disease is B-cell chronic lymphocytic leukemia.