Constitutive expression of COX-2 is a biomarker of tumor cell aggressiveness [44], but the inducible nuclear pool of the enzyme has a wholly different function in resveratrol-exposed cells [21, 43, 45, 46] in which it forms complexes with pERK1/2, p53 and SUMO-1 to act as a co-activator for p53-responsive genes [47]. The gene discussed is TP53; the disease is neoplasm.