To delineate whether the miR- 23b-suppressed progression of gastric cancer cells is through down-regulating Notch2 receptor or Ets1, the miR-23b-insensitive N2IC-expressing SC-M1/myc-N2IC-His cells and SC-M1 cells transfected with miR- 23b-insensitive Ets1-expressing construct were infected with miR-23b-expressing adenoviruses for the subsequent tumorsphere formation, colony formation, migration, and invasion assays. The gene discussed is ETS1; the disease is gastric cancer.