IGF1R and non-small cell lung carcinoma: Importantly, co-targeting IGF-1R and Src exhibited apoptotic activities in vitro in both high-pSrc-expressing and low-pSrc-expressing NSCLC cell lines as well as in vivo in immunodeficient mice bearing xenograft tumors of these cell lines and in those bearing heterotransplant xenogrft tumors from a patient with NSCLC.