Enhanced effects of co-targeting IGF-1R and Src on viability (Additional file 18: Figure S17A), anchorage-dependent (Additional file 18: Figure S17B) and anchorage-independent colony formation (Additional file 18: Figure S17C) were also observed in both high-pSrc-expressing and low-pSrc-expressing NSCLC cells when another pharmacologic SFK inhibitor, PP2 [26], was combined with linsitinib. This evidence concerns the gene SRC and non-small cell lung carcinoma.