In this work, we show that 1) Src acts as a common downstream node of multiple membrane-associated receptors, including IGF-1R, EGFR, and integrin, stimulating downstream molecules, such as Akt, to sustain cell viability (Fig. 6a); 2) Src and IGF-1R are reciprocally co-activated at high levels in the majority of NSCLC cells. Here, EGFR is linked to non-small cell lung carcinoma.