In fact, in MDA-MB231 breast carcinoma cells, that did not show E-cadherin, HGF was ineffective on Twist expression/transactivating activity and Snail expression, while in HepG2 hepatocarcinoma cells HGF induces upregulation of Snail through MAPK/Erg-1 pathway, without affecting Twist, leading to downregulation of E-cadherin [38]. The gene discussed is SNAI1; the disease is breast carcinoma.