Freshly isolated primary leukemic cells from 5 CLL patients were treated for 24 h with 5 μM of each MCNA, alone or in combination with 25 μM bendamustine followed by AnnexinV/7AAD flow cytometry and immunoblot (PARP cleavage) analysis. The gene discussed is ANXA5; the disease is B-cell chronic lymphocytic leukemia.