ANXA5 and B-cell chronic lymphocytic leukemia: Flow cytometry with AnnexinV (early-apoptotic surface expression of the neoepitope phosphatidyl-serine) combined with 7AAD or Hoechst stain (uptake upon late-apoptotic or necrosis-associated membrane disintegration) assayed the ability of our MCNA to trigger death of primary tumor cells from CLL patients and of healthy-donor derived PBMC.