Some of the positions that came out of our analysis as the most crucial for peptide-binding preferences have previously been shown to be associated with an increased risk of transplantation-related diseases (positions 9 and 116 in HLA-A and position 116 in HLA-B; Ferrara et al. 2001; Kawase et al. 2007). The gene discussed is HLA-B; the disease is disease related to transplantation.