We chose to test the predictions for GCLC, GSS, SLC7A9 (considered essential in silico for ccRCC because they were classified as such in 5 of the 7 cell lines), and PNP (considered nonessential in silico for ccRCC because it was classified as such in 3 of the 7 cell lines). This evidence concerns the gene GSS and nonpapillary renal cell carcinoma.