We chose to test the predictions for GCLC, GSS, SLC7A9 (considered essential in silico for ccRCC because they were classified as such in 5 of the 7 cell lines), and PNP (considered nonessential in silico for ccRCC because it was classified as such in 3 of the 7 cell lines). The gene discussed is SLC7A9; the disease is nonpapillary renal cell carcinoma.