GPAT4 and nonpapillary renal cell carcinoma: In the human metabolic network, the AGPAT6-encoded reaction, i.e., the conversion of glycerol-3-phosphate to 1-acyl-glycerol-3-phosphate, is associated with additional isoenzymes, AGPAT9, GPAT2, and GPAM. However, according to the Human Protein Atlas, which supported the reconstruction of the ccRCC metabolic network, AGPAT6 is the only member of the family of lysophosphatidic acid acyltransferase genes appreciably expressed in ccRCC56.